A variant of the IL7 gene predicts the toxicity of checkpoint inhibitors in patients with cancer, via a mechanism shared with autoimmune diseases — which could inform biomarker and treatment strategies in both of these contexts.
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C.R. is an occasional consultant for Roche, BMS, MSD, Sanofi, AstraZeneca, Pierre Fabre, Novartis and scientific co-Founder of Ribonexus; S.V. is scientific co-founder of Ribonexus Xavier Mariette is an occasional consultant for AstraZeneca, Novartis, BMS, Galapagos, Pfizer, GSK.
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Robert, C., Vagner, S. & Mariette, X. Using genetics to predict toxicity of cancer immunotherapy. Nat Med 28, 2471–2472 (2022). https://doi.org/10.1038/s41591-022-02096-4
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DOI: https://doi.org/10.1038/s41591-022-02096-4