Evidence — provided by a combination of amyloid-β and tau PET examinations — of advanced Alzheimer’s disease pathological changes in the brain in cognitively unimpaired individuals is strongly associated with short-term (3–5 years) cognitive decline. Thus, amyloid-β and tau PET have high clinical relevance.
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References
Jansen, W. et al. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. JAMA 313, 1924–1938 (2015). A meta-analysis showing that age and APOE genotype are the main risk factors for an abnormal amyloid-β PET scan.
Braak, H. & Braak, E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239–259 (1993). This paper reports a post-mortem staging system of neurofibrillary tau pathology, which increases with advancing age.
Ossenkoppele, R. et al. Tau biomarkers in Alzheimer’s disease: towards implementation in clinical practice and trials. Lancet Neurol. 21, 726–734 (2022). A Review article that discusses the current state of tau biomarkers and how they can improve clinical practice and trials.
Jack, C. R. Jr et al. NIA-AA Research Framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 14, 535–556 (2018). A consensus paper of a research framework proposing a biomarker-based definition of AD.
Dubois, B. et al. Clinical diagnosis of Alzheimer’s disease: recommendations of the International Working Group. Lancet Neurol. 20, 484–496 (2021). A consensus paper proposing that the term AD should be restricted to symptomatic individuals.
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This is a summary of: Hansson, O. et al. et al. Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline. Nat. Med. https://doi.org/10.1038/s41591-022-02049-x (2022).
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Amyloid-β and tau PET scans predict clinical progression in cognitively unimpaired people. Nat Med 28, 2267–2268 (2022). https://doi.org/10.1038/s41591-022-02071-z
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DOI: https://doi.org/10.1038/s41591-022-02071-z