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The clonal evolution of Richter transformation cells uncovers therapeutic vulnerabilities

The commonly indolent chronic lymphocytic leukemia may evolve into Richter transformation (RT), a very aggressive large B cell lymphoma. We identified early seeding of RT cells decades before its final expansion, mapped the underlying (epi)genomic alterations driving this process, and validated in vitro potential actionable therapeutic pathways.

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Fig. 1: RT cells.


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This is a summary of: Nadeu, F. et al. Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. Nat. Med. (2022).

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The clonal evolution of Richter transformation cells uncovers therapeutic vulnerabilities. Nat Med 28, 1546–1547 (2022).

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