Genetic ancestry affects human health, but this is distinct from the impact of race, a social construct that has its foundations in systemic racism. These terms need to be better defined and understood in medical research to achieve health equity.
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Goldberg, D. Ethn. Racial Stud. 15, 543–569 (1992).
Barot, R. et al. Ethn. Racial Stud. 24, 601–618 (2001).
Hsu, C. Y. et al. N. Engl. J. Med. 385, 1750–1760 (2021).
Mathieson, I. et al. PLoS Genet. 16, e1008624 (2020).
Mersha, T. B. et al. Hum. Genomics 9, 1 (2015).
Braveman, P. et al. Front. Public Health 9, 689462 (2021).
Templeton, A. Stud. Hist. Philos. Biol. Biomed. Sci. 44, 262–271 (2013).
Omi, M. et al. Racial Formation in the United States 3rd edn. (Routledge, 2014).
Fuentes, A. et al. Am. J. Phys. Anthropol. 169, 400–402 (2019).
Office of the Assistant Secretary for Planning and Evaluation. HHS-DATA https://aspe.hhs.gov/collaborations-committees-advisory-groups/hhs-data/hhs-data-council-introduction/dc-archive/policy-statement-inclusion-race-ethnicity-dhhs-data-collection-activities (2021).
Manrai, A. K. et al. N. Engl. J. Med. 375, 655–665 (2016).
Awasthi,, S. et al. Clin. Cancer Res. 27, 320–329 (2021).
Mahal, B. A. et al. N. Engl. J. Med. 383, 1083–1085 (2020).
Cooperberg, M. R. et al. Eur. Urol. 74, 444–452 (2018).
Rebbeck, T. R. et al. Cancer Discov. 8, 803–811 (2018).
Friebel, T. M. et al. Hum. Mutat. 40, 1781–1796 (2019).
DeSantis, C. E. et al. CA Cancer J. Clin. 69, 438–451 (2019).
This work was supported in part by Department of Defense award CDMRP-PC181013 and Prostate Cancer Foundation (K.Y.); National Cancer Institute grant P20-CA233255 (K.Y. and T.R.R.); Jean Perkins Foundation, STOP Cancer Foundation, National Cancer Institute and Specialized Programs of Research Excellence grant P50 CA092131 and Prostate Cancer Foundation Challenge Award 17CHAL04 (I.P.G.); and National Institutes of Health (K08CA215312), Burroughs Wellcome Foundation (1017184), Basser Center for BRCA at the University of Pennsylvania, and the Prostate Cancer Foundation (K.M.).
T.R.R.’s wife is a consultant to AstraZeneca. All other authors declare no competing interests.
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Rebbeck, T.R., Mahal, B., Maxwell, K.N. et al. The distinct impacts of race and genetic ancestry on health. Nat Med 28, 890–893 (2022). https://doi.org/10.1038/s41591-022-01796-1