Clinical trial results show that psilocybin, a potent psychedelic, has antidepressant effects in patients with depression and is more effective than escitalopram. Functional MRI experiments revealed a decrease in brain modularity after psilocybin therapy, indicative of an increase in the global integration of the brain’s functional networks.
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References
Beck, A. T. & Clark, D. A. Anxiety and depression: an information processing perspective. Anxiety 1, 23–26 (1988). A review article that presents Aaron Beck’s cognitive theory of depression.
Carhart-Harris, R. L. & Nutt, D. J. Serotonin and brain function: a tale of two receptors. J. Psychopharmacol. 31, 1091–1120 (2017). A review article of serotonin’s role in brain function and the action of conventional antidepressants.
Carhart-Harris, R. L. et al. Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry 3, 619–627 (2016). A paper reporting that psilocybin alleviates depression in treatment-resistant patients.
Roseman, L. et al. The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers. Front. Hum. Neurosci. 8, 204 (2014). A paper that presents evidence of increased fMRI between-network integration during acute psilocybin treatment.
Hamilton, J. P. et al. Default-mode and task-positive network activity in major depressive disorder: implications for adaptive and maladaptive rumination. Biol. Psychiatry 70, 327–333 (2011). A paper that presents abnormal fMRI brain function in depression.
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This is a summary of: Daws, R. E. et al. Increased global integration in the brain after psilocybin therapy for depression. Nat. Med. https://doi.org/10.1038/s41591-022-01744-z (2022).
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Psilocybin increases brain network integration in patients with depression. Nat Med 28, 647–648 (2022). https://doi.org/10.1038/s41591-022-01769-4
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DOI: https://doi.org/10.1038/s41591-022-01769-4
