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CANCER IMMUNOTHERAPY

CAR T cells reach clinical milestone in prostate cancer

Nature Medicine volume 28, pages 635–636 (2022)Cite this article

Armored CAR T cells show early signs of clinical activity in patients with castration-resistant prostate cancer, paving the way for further development and optimization.

Cancer progression is often fueled by a preponderance of genetic aberrations such as mutations, amplifications and divergently expressed genes. These can lead to newly expressed peptides (known as ‘tumor-specific antigens’ or ‘neoantigens’) that are entirely absent from normal (non-cancerous) human tissues, or to peptides that are expressed at higher levels in tumors, but are also expressed at lower levels in other tissues — the latter are known as ‘tumor-associated antigens’.

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Fig. 1: Mechanism of PSMA-directed, TGF-β-armored CAR T cells in castrate-resistant prostate cancer.

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Authors and Affiliations

  1. Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA

    Nicholas P. Tschernia, Scott M. Norberg & James L. Gulley

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  1. Nicholas P. Tschernia
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  2. Scott M. Norberg
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  3. James L. Gulley
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Correspondence to James L. Gulley.

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N.P.T., S.M.N. and J.L.G. are employees of the National Cancer Institute, US National Institutes of Health.

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Tschernia, N.P., Norberg, S.M. & Gulley, J.L. CAR T cells reach clinical milestone in prostate cancer. Nat Med 28, 635–636 (2022). https://doi.org/10.1038/s41591-022-01742-1

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