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Context matters in CAR T cell tonic signaling

Unexpected clinical results unearth a new facet in CAR design that could facilitate the development of more-effective CAR T cell therapies.

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Correspondence to Kristen Hege.

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Competing interests

K.H. is an employee and stockholder of Bristol Myers Squibb; an independent board of directors member and stockholder of Mersana Therapeutics; and a volunteer faculty member in the Division of Hematology/Oncology at the University of California San Francisco.

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Hege, K. Context matters in CAR T cell tonic signaling. Nat Med 27, 763–764 (2021).

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