A precision medicine–based strategy for a severe adverse drug reaction

Detailed single-cell RNA-sequencing analysis of skin and blood from a patient with DRESS, a severe adverse drug reaction, leads to a personalized, hypothesis-driven treatment.

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Fig. 1: Precision-medicine pipeline for severe adverse drug reactions in drug-induced hypersensitivity and DRESS.


  1. 1.

    Sultana, J., Cutroneo, P. & Trifirò, G. J. Pharmacol. Pharmacother. 4, S73–S77 (2013).

    Article  Google Scholar 

  2. 2.

    Schatz, S.N. & Weber, R.J. in PSAP: CNS/Pharmacy Practice (eds. Lee, M. W. & Murphy, J. E.) 5–26 (American College of Clinical Pharmacy, 2015).

  3. 3.

    Mockenhaupt, M. Allergol. Sel. 1, 96–108 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Cho, Y. T. & Chu, C. Y. J. Immunol. Res. 2017, 1503709 (2017).

    Article  Google Scholar 

  5. 5.

    Kim, D. et al. Nat. Med. (2019).

  6. 6.

    Cho, Y.-T., Yang, C.-W. & Chu, C.-Y. Int. J. Mol. Sci. 18, 1243 (2017).

    CAS  Article  Google Scholar 

  7. 7.

    Chen, C.-B. et al. J. Immunol. Res. 2018, 6431694 (2018).

    PubMed  PubMed Central  Google Scholar 

  8. 8.

    Kardaun, S. H. et al. Br. J. Dermatol. 156, 609–611 (2007).

    CAS  Article  Google Scholar 

  9. 9.

    Miyagawa, F. et al. J. Dermatol. Sci. 83, 151–154 (2016).

    CAS  Article  Google Scholar 

  10. 10.

    Damsky, W. E. et al. JAAD Case Rep. 5, 1018–1026 (2019).

    Article  Google Scholar 

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Correspondence to Brian S. Kim.

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Competing interests

B.S.K. has served as a consultant for AbbVie, Concert Pharmaceuticals, Incyte, Menlo Therapeutics, and Pfizer; is the founder and chief scientific officer of Nuogen Pharma; and has participated in advisory boards for Cara Therapeutics, Celgene, Kiniksa Pharmaceuticals, Menlo Therapeutics, Regeneron Pharmaceuticals, Sanofi, and Theravance Biopharma.

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Mack, M.R., Kim, B.S. A precision medicine–based strategy for a severe adverse drug reaction. Nat Med 26, 167–168 (2020).

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