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Liver metastases inhibit immunotherapy efficacy

Liver metastases lead to resistance to immunotherapy through the ‘siphoning’ of tumor antigen–specific CD8+ T cells into the liver, which results in a systemic ‘immune desert’ incapable of controlling tumor burden.

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Fig. 1: Proposed mechanism by which liver metastases result in resistance to immunotherapy.


  1. 1.

    Sharma, P., Hu-Lieskovan, S., Wargo, J. A. & Ribas, A. Cell 168, 707–723 (2017).

    CAS  Article  Google Scholar 

  2. 2.

    Yu, J. et al. Nat. Med. (2020).

  3. 3.

    Forrester, J. V., Xu, H., Lambe, T. & Cornall, R. Mucosal Immunol. 1, 372–381 (2008).

    CAS  Article  Google Scholar 

  4. 4.

    Medina-Echeverz, J., Eggert, T., Han, M. & Greten, T. F. Cancer Immunol. Immunother. 64, 931–940 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Qian, B. Z. & Pollard, J. W. Cell 141, 39–51 (2010).

    CAS  Article  Google Scholar 

  6. 6.

    Twyman-Saint Victor, C. et al. Nature 520, 373–377 (2015).

    CAS  Article  Google Scholar 

  7. 7.

    Lee, J. C. et al. Sci. Immunol. 5, eaba0759 (2020).

    CAS  Article  Google Scholar 

  8. 8.

    Finn, R. S. et al. N. Engl. J. Med. 382, 1894–1905 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Mantovani, A., Marchesi, F., Malesci, A., Laghi, L. & Allavena, P. Nat. Rev. Clin. Oncol. 14, 399–416 (2017).

    CAS  Article  Google Scholar 

  10. 10.

    Villanueva, A. N. Engl. J. Med. 380, 1450–1462 (2019).

    CAS  Article  Google Scholar 

  11. 11.

    Ringelhan, M., Pfister, D., O’Connor, T., Pikarsky, E. & Heikenwalder, M. Nat. Immunol. 19, 222–232 (2018).

    CAS  Article  Google Scholar 

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Correspondence to Amaia Lujambio.

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Lindblad, K.E., Lujambio, A. Liver metastases inhibit immunotherapy efficacy. Nat Med 27, 25–27 (2021).

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