Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Extrapulmonary SARS-CoV-2 manifestations

Ann. Intern. Med. (2020)

The infection of the upper and lower respiratory tract that becomes life-threatening pneumonia in severe cases is the hallmark of COVID-19. But SARS-CoV-2 infection is not always limited to the respiratory system.

A series of autopsies performed at the University Medical Center Hamburg-Eppendorf on twelve PCR-confirmed cases of COVID-19 found detectable SARS-CoV-2 in the blood of six patients. Of those six, five showed viral RNA titers in the liver, kidneys or heart. The study also supported the possibility of a role for coagulopathy in COVID-19, as seven of the twelve patients had signs of deep venous thrombosis and, for four patients, pulmonary embolism was the direct cause of death.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Thiago Carvalho.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Carvalho, T. Extrapulmonary SARS-CoV-2 manifestations. Nat Med 26, 1806 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing