Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PUBLIC HEALTH

Implications of legacy lead for children’s brain development

Children at a higher risk of lead exposure develop smaller brain cortical surface area and volume, but only if they are from low-income families.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Timeline of consumption of lead in gasoline in the USA and mean population blood-lead levels across the past 100 years.

References

  1. Ettinger, A. S., Ruckart, P. Z. & Dignam, T. J. Public Health Manag. Pract. 25, S1–S2 (2019).

    Article  Google Scholar 

  2. Bellinger, D. C. Curr. Opin. Pediatr. 20, 172–177 (2008).

    Google Scholar 

  3. Marshall, A.T. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0713-y (2020).

  4. Lessler, M. A. Ohio J. Sci. 88, 78–84 (1988).

    CAS  Google Scholar 

  5. Lidsky, T. I. & Schneider, J. S. Brain 126, 5–19 (2003).

    Article  Google Scholar 

  6. Nriagu, J.O. Lead and Lead Poisoning in Antiquity (Wiley, 1983).

  7. Trahan, L. H., Stuebing, K. K., Fletcher, J. M. & Hiscock, M. Psychol. Bull. 140, 1332–1360 (2014).

    Article  Google Scholar 

  8. Drum, K. Mother Jones (2013).

  9. Weiss, B. & Bellinger, D. C. Environ. Health Perspect. 114, 1479–1485 (2006).

    Article  CAS  Google Scholar 

  10. Rosner, D. & Markowitz, G. Public Health Rep. 120, 330–337 (2005).

    Article  Google Scholar 

  11. Reuben, A. J. Alzheimers Dis. 64, 17–42 (2018).

    Article  Google Scholar 

  12. Eid, A. & Zawia, N. Neurotoxicology 56, 254–261 (2016).

    Article  CAS  Google Scholar 

  13. Nriagu, J. O. Sci. Total Environ. 92, 13–28 (1990).

    Article  CAS  Google Scholar 

  14. Thomas, V. M., Socolow, R. H., Fanelli, J. J. & Spiro, T. G. Environ. Sci. Technol. 33, 3942–3948 (1999).

    Article  CAS  Google Scholar 

  15. National Center for Environmental Health Sciences. https://doi.org/10.15620/cdc75822 (2019).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Avshalom Caspi.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Reuben, A., Elliott, M. & Caspi, A. Implications of legacy lead for children’s brain development. Nat Med 26, 23–25 (2020). https://doi.org/10.1038/s41591-019-0731-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-019-0731-9

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing