NEURODEGENERATION

A novel pathway for microbial metabolism of levodopa

Particular bacteria from the gut microbiota metabolize levodopa (l-dopa), reducing bioavailability of the drug for treating Parkinson’s disease.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Redkal et al. identify a novel pathway for microbial metabolism of l-dopa.

References

  1. 1.

    Sampson, T. R. et al. Cell 167, 1469–1480.e12 (2016).

  2. 2.

    Papavasiliou, P. S. et al. N. Engl. J. Med. 286, 8–14 (1972).

  3. 3.

    Bedarf, J. R. et al. Genome Med. 9, 39 (2017).

  4. 4.

    Hashim, H. et al. PLOS One 9, e112330 (2014).

  5. 5.

    Fasano, A. et al. Mov. Disord. 28, 1241–1249 (2013).

  6. 6.

    Zhu, H. et al. Sci. Rep. 6, 27779 (2016).

  7. 7.

    Whitfield, A. C. et al. ACS Chem. Neurosci. 5, 1192–1197 (2014).

  8. 8.

    Zimmermann, M. et al. Nature 570, 462–467 (2019).

  9. 9.

    Zimmermann, M. et al. Science 363, 6427 (2019).

Download references

Author information

Correspondence to K. G. Jameson.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark