NEURODEGENERATION

A fresh look at adult neurogenesis

Improved protocols for the visualization of immature neurons in the human brain provide evidence for generation of neurons in the adult hippocampus and uncover reduced neurogenesis in Alzheimer’s disease.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: The number of immature neurons in the human hippocampus decreases in AD.

References

  1. 1.

    Goncalves, J. T., Schafer, S. T. & Gage, F. H. Cell 167, 897–194 (2016).

  2. 2.

    Moreno-Jiménez, E. P. et al. Nat. Med. https://doi.org/10.1038/s41591-019-0375-9 (2019).

  3. 3.

    Kempermann, G. et al. Cell Stem Cell 23, 25–30 (2018).

  4. 4.

    Knoth, R. et al. PLoS One 5, e8809 (2010).

  5. 5.

    Boldrini, M. et al. Cell Stem Cell 22, 589–599.e585 (2018).

  6. 6.

    Sorrells, S. F. et al. Nature 555, 377–381 (2018).

  7. 7.

    Lucassen, P. J. et al. Mol. Psychiatry https://doi.org/10.1038/s41380-018-0337-5 (2019).

  8. 8.

    Spalding, K. L. et al. Cell 153, 1219–1227 (2013).

  9. 9.

    Eriksson, P. S. et al. Nat. Med. 4, 1313–1317 (1998).

  10. 10.

    Jin, K.et al. Proc. Natl Acad. Sci. USA 101, 343–347 (2004).

  11. 11.

    Boekhoorn, K., Joels, M. & Lucassen, P. J. Neurobiol. Dis. 24, 1–14 (2006).

  12. 12.

    Li, B.et al. J. Neuropathol. Exp. Neurol. 67, 78–84 (2008).

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jonas Frisén.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Steiner, E., Tata, M. & Frisén, J. A fresh look at adult neurogenesis. Nat Med 25, 542–543 (2019). https://doi.org/10.1038/s41591-019-0408-4

Download citation

Further reading

Search

Quick links

Sign up for the Nature Briefing newsletter for a daily update on COVID-19 science.
Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing