Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

IMMUNOTHERAPY

Targeting the cancer mutanome of breast cancer

A metastatic hormone receptor–positive breast cancer, usually resistant to immunotherapy, is successfully treated with tumor-infiltrating lymphocytes enriched for neoantigen reactivity, underscoring the broad potential of this immunotherapeutic approach.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Adoptive T cell therapy successfully treats a metastatic hormone receptor–positive breast cancer.

References

  1. 1.

    Campbell, B. B. et al. Cell 171, 1042–1056.e1010 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. 2.

    Alvarez, B., Barra, C., Nielsen, M. & Andreatta, M. Proteomics https://doi.org/10.1002/pmic.201700252 (2018).

  3. 3.

    Efremova, M., Finotello, F., Rieder, D. & Trajanoski, Z. Front. Immunol. 8, 1679 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Dudley, M. E. et al. Science 298, 850–854 (2002).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. 5.

    Rosenberg, S. A. Nat. Rev. Clin. Oncol. 8, 577–585 (2011).

    Article  PubMed  CAS  Google Scholar 

  6. 6.

    Goodman, A. M. et al. Mol. Cancer Ther. 16, 2598–2608 (2017).

    Article  PubMed  CAS  Google Scholar 

  7. 7.

    Schumacher, T. N. & Hacohen, N. Curr. Opin. Immunol. 41, 98–103 (2016).

    Article  PubMed  CAS  Google Scholar 

  8. 8.

    Zacharakis, N. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0040-8 (2018).

  9. 9.

    Bobisse, S. et al. Nat. Commun. 9, 1092 (2018).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. 10.

    Robbins, P. F. et al. Nat. Med. 19, 747–752 (2013).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. 11.

    Kreiter, S. et al. Nature 520, 692–696 (2015).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. 12.

    Chowell, D. et al. Science 359, 582–587 (2018).

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The author thanks all colleagues and scientists who over the years have shared ideas and concepts and have worked diligently to develop cell therapy and vaccination for cancer, bringing it to the forefront of immunotherapy.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Laszlo G. Radvanyi.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Radvanyi, L.G. Targeting the cancer mutanome of breast cancer. Nat Med 24, 703–704 (2018). https://doi.org/10.1038/s41591-018-0065-z

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing