A landmark study reveals how Kupffer cells, resident macrophages of the liver, can promote antitumor immunity. Central to this function is ID3, a Kupffer cell lineage-determining factor. The findings provide new insights into cancer therapy.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Deng, Z. et al. Nature https://doi.org/10.1038/s41586-023-06950-4 (2024).
Cassetta, L. & Pollard, J. W. Nat. Rev. Cancer 23, 238–257 (2023).
Pittet, M. J., Michielin, O. & Migliorini, D. Nat. Rev. Clin. Oncol. 19, 402–421 (2022).
Hanahan, D. Cancer Discov. 12, 31–46 (2022).
Binnewies, M. et al. Nat. Med. 24, 541–550 (2018).
Franklin, R. A. et al. Science 344, 921–925 (2014).
Zhu, Y. et al. Immunity 47, 323–338.e6 (2017).
Casanova-Acebes, M. et al. Nature 595, 578–584 (2021).
Nalio Ramos, R. et al. Cell 185, 1189–1207.e25 (2022).
Paget, S. Lancet 133, 571–573 (1889).
Siwicki, M. et al. Sci. Immunol. 6, eabi7083 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
M.J.P. has served as a consultant for AstraZeneca, Elstar Therapeutics, ImmuneOncia, KSQ Therapeutics, LegoChem Bio, Merck, Siamab Therapeutics, Third Rock Ventures, Tidal and Unikum.
Rights and permissions
About this article
Cite this article
Goubet, AG., Pittet, M.J. Unveiling the antitumor function of ID3 in liver macrophages. Nat Immunol 25, 394–395 (2024). https://doi.org/10.1038/s41590-024-01761-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-024-01761-9