Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.
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Acknowledgements
C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/SBSRF/22/31031[CM1]).
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Gope, A., Mauro, C. When ceramides meet immune senescence, a GIMAP5 connection. Nat Immunol 25, 196–197 (2024). https://doi.org/10.1038/s41590-023-01736-2
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DOI: https://doi.org/10.1038/s41590-023-01736-2