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SARS-CoV-2

Activation-based repertoire analysis for T cell clonal dynamics in hybrid COVID-19 immunity

Nature Immunology volume 25, pages 7–8 (2024)Cite this article

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The use of T cell receptor signatures to track activated spike-specific T cell dynamics between recovery from SARS-CoV-2 infection and subsequent mRNA vaccination shows that vaccination effectively recruits pre-existing memory and new CD8+ T cell clonotypes.

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Fig. 1: Vaccination boosts and expands SARS-CoV-2 infection-generated CD8+ T cell TCR clonotypes with new clonotypes recruited at subsequent doses.

References

  1. Ford, E. S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01692-x (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Alsoussi, W. B. et al. Nature 617, 592–598 (2023).

    Article  CAS  PubMed  Google Scholar 

  3. Goel, R. R. et al. Sci. Immunol. 6, eabi6950 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Reynolds, C. J. et al. Science 377, eabq1841 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Rowntree, L. C. et al. Immunity 55, 1299–1315.e1294 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Minervina, A. A. et al. Nat. Immunol. 23, 781–790 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Soerens, A. G. et al. Nature 614, 762–766 (2023).

    Article  CAS  PubMed  Google Scholar 

  8. Lim, J. M. E. et al. J. Exp. Med. 219 (2022).

  9. Koutsakos, M. et al. Immunity 56, 879–892/e874 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Goncharov, M. et al. Nat. Methods 19, 1017–1019 (2022).

    Article  CAS  PubMed  Google Scholar 

  11. Mudd, P. A. et al. Cell 185, 603–613.e615 (2022).

    Article  CAS  PubMed  Google Scholar 

  12. Pogorelyy, M. V. et al. Cell Rep Med. 3, 100697 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors are supported by an NHMRC fellowship (S.A.V.), theme-based research scheme of the research grants council (RGC) of HKSAR grant no. T11-705/21-N (S.A.V.), HKPF from the HKSAR RGC (C.A.C.).

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  1. These authors contributed equally: Louise C. Rowntree, Carolyn A. Cohen.

Authors and Affiliations

  1. Department of Microbiology and Immunology, Peter Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

    Louise C. Rowntree & Sophie A. Valkenburg

  2. HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China

    Carolyn A. Cohen & Sophie A. Valkenburg

Authors
  1. Louise C. Rowntree
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  2. Carolyn A. Cohen
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  3. Sophie A. Valkenburg
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Correspondence to Sophie A. Valkenburg.

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Rowntree, L.C., Cohen, C.A. & Valkenburg, S.A. Activation-based repertoire analysis for T cell clonal dynamics in hybrid COVID-19 immunity. Nat Immunol 25, 7–8 (2024). https://doi.org/10.1038/s41590-023-01695-8

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