A trimodal single-cell assay reveals a previously unknown T cell subset and cellular state differences between children and older adults that might contribute to age-specific immunity.
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References
Goronzy, J. J. & Weyand, C. Mechanisms underlying T cell ageing. Nat. Rev. Immunol. 19, 573–583 (2019). A review that provides an overview of different aspects of aging that affect the T cell compartment.
Mittelbrunn, M. & Kroemer, G. Hallmarks of T cell aging. Nat. Immunol. 22, 687–698 (2021). A review that presents the features of T cell aging.
Swanson, E. et al. Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq. eLife 10, e63632 (2021). This paper reports the development of the TEA-seq assay.
Kurioka, A. & Klenerman, P. Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging. Semin. Immunol. 69, 101816 (2023). A review that describes unconventional T cell subsets and their changes with age.
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This is a summary of: Thomson, Z. et al. Trimodal single cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment. Nat. Immunol. https://doi.org/10.1038/s41590-023-01641-8 (2023).
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Unraveling age-specific complexity in the human T cell compartment. Nat Immunol 24, 1799–1800 (2023). https://doi.org/10.1038/s41590-023-01653-4
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DOI: https://doi.org/10.1038/s41590-023-01653-4
