Kupffer cells, hepatic resident macrophages, are the first line of defense against liver metastases by engulfing disseminated malignant cells. We found that ERMAP expressed on tumor cells binds to galectin-9 and dectin-2 on Kupffer cells to deliver pro-phagocytosis ‘eat me’ signals to Kupffer cells to restrict liver metastases.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Mielgo, A. & Schmid, M. C. Liver Tropism in cancer: the hepatic metastatic niche. Cold Spring Harb. Perspect. Med. 10, a037259 (2020). A review article that presents the features of the hepatic metastatic niche.
Chen, J. et al. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature 544, 493–497 (2017). This paper reports SLAMF7 as a pro-phagocytosis signal specific to hematopoietic tumor cells.
Jaiswal, S. et al. CD47 Is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 138, 271–285 (2009). This paper reports the classical anti-phagocytosis signal CD47.
Barkal, A. A. et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature 572, 392–396 (2019). This paper reports the anti-phagocytosis signal CD24.
Pinho, S. S. & Reis, C. A. Glycosylation in cancer: mechanisms and clinical implications. Nat. Rev. Cancer 15, 540–555 (2015). A review article that presents glycosylation aspects in cancer.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Li, J. et al. The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity. Nat. Immunol. https://doi.org/10.1038/s41590-023-01634-7 (2023).
Rights and permissions
About this article
Cite this article
ERMAP activates phagocytosis in Kupffer cells to restrict liver metastases. Nat Immunol 24, 1801–1802 (2023). https://doi.org/10.1038/s41590-023-01647-2
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-023-01647-2
