Genetic and environmental diversity are major drivers of macrophage transcriptional responses, but the mechanisms that underlie the relative contributions of gene-by-environment interactions to transcriptional responses of tissue macrophages are unclear. We defined the relative effect of cis regulation, cell-autonomous trans regulation, and non-cell-autonomous trans regulation of Kupffer cell gene expression.
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This is a summary of: Bennett, H. et al. Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. Nat. Immunol. https://doi.org/10.1038/s41590-023-01631-w (2023).
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Gene-by-environment regulation of Kupffer cell transcriptomes and epigenomes. Nat Immunol 24, 1797–1798 (2023). https://doi.org/10.1038/s41590-023-01643-6
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DOI: https://doi.org/10.1038/s41590-023-01643-6
