Human mucosal-associated invariant T (MAIT) cells exhibit many functions, but whether this reflects different subsets is unknown. We defined the transcriptional and clonal landscape of MAIT cells in human blood and liver. Our study reveals limited transcriptional variation within tissues, but marked phenotypic and functional plasticity according to tissue, clone, and most notably, stimulus.
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References
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This is a summary of: Garner, L. C. et al. Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity. Nat. Immunol. https://doi.org/10.1038/s41590-023-01575-1 (2023).
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Single-cell diversity and functional plasticity of human MAIT cells. Nat Immunol 24, 1409–1410 (2023). https://doi.org/10.1038/s41590-023-01600-3
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DOI: https://doi.org/10.1038/s41590-023-01600-3
