Naive B cells activated during infection enter the germinal center (GC) reaction, in which high-affinity antibodies are generated. A new study has uncovered a distinct metabolic requirement for B cells poised to undergo the GC reaction, whose activation required lactate dehydrogenase A-dependent aerobic glycolysis.
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Brownlie, R.J., Klein, U. B cells ferment sugar before they (affinity) mature. Nat Immunol 24, 1217–1219 (2023). https://doi.org/10.1038/s41590-023-01536-8
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DOI: https://doi.org/10.1038/s41590-023-01536-8