Mononuclear phagocyte proliferation is thought to be limited to myeloid progenitor cells and mature macrophages. However, availability within an interstitial macrophage niche permits the proliferation of monocytes in the lung before macrophage differentiation.
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The authors declare no competing interests.
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Khan, A.B., Robbins, C.S. Macrophage niche availability enables local monocyte proliferation in peripheral tissues. Nat Immunol 24, 743–745 (2023). https://doi.org/10.1038/s41590-023-01482-5