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Autoinflammatory disease

Targeting G-CSF to treat autoinflammation

Nature Immunology volume 24, pages 736–737 (2023)Cite this article

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APLAID is a very rare autoinflammatory disease thought to be caused by mutations in PLCG2. A mouse model of APLAID recapitulates clinical features of the disease, and identifies a crucial function for G-CSF that might be targeted therapeutically.

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Fig. 1: A new model of autoinflammation and emerging treatment options.

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Authors and Affiliations

  1. Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK

    Tom D. Bunney & Matilda Katan

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  1. Tom D. Bunney
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  2. Matilda Katan
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Correspondence to Matilda Katan.

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The authors declare no competing interests.

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Bunney, T.D., Katan, M. Targeting G-CSF to treat autoinflammation. Nat Immunol 24, 736–737 (2023). https://doi.org/10.1038/s41590-023-01474-5

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