Intrathymic dendritic cell (DC)-biased precursors act as hematopoietic stromal cells that support the generation of human T cell progenitors from hematopoietic progenitor cells, via crosstalk with immature thymocytes that express TNF receptor 2. This function of DC precursors can be exploited to generate T cell precursors and competent T cells for cell therapy.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Moirangthem, R. D. et al. A DL-4- and TNFα based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors. Cell, Mol lmmunol 18, 1662–1676 (2021). This paper reports the use of sTNF to generate human T cell progenitors.
Lavaert, M. et al. Integrated scRNA-seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes. Immunity 52, 1088–1104 (2020). This paper reports the two types of thymus seeding progenitor cells in human postnatal thymus.
Edgar, J. M. et al. Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development. NPJ Regen. Med. 7, 11 (2022). This paper reports sTNF as a stage-specific and dose -specific enhancer of T cell-lineage differentiation.
Seel, C. S. et al. Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids. Nat. Methods 14, 521–530 (2021). This paper establishes an organoid system for three-dimensional in vitro modelling of T cell development.
Fischer, R. et al. Selective targeting of TNF Receptors as a novel therapeutic approach. Front. Cell Dev. Biol. 8, 401 (2020). This review article discusses the differential roles of the two TNF receptors and their selective targeting.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Liang, K. L. et al. Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Nat. Immunol. https://doi.org/10.1038/s41590-022-01417-6 (2023).
Rights and permissions
About this article
Cite this article
Dendritic cell-biased precursors support early human thymopoiesis. Nat Immunol 24, 389–390 (2023). https://doi.org/10.1038/s41590-023-01421-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-023-01421-4