Understanding immune determinants of vaccine-mediated immunogenicity could further provide rational vaccine design. Two research groups revealed pre-existing and early innate immune signatures associated with better vaccine-mediated antibody responses.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
02 December 2022
In the version of this article initially published, the mention of Steven Kleinstein was missing from the first paragraph summary now reading “In this issue of Nature Immunology, the groups of Kleinstein, Sekaly and Pulendran used systems-based approaches to address this challenge”. The change has been made to the HTML and PDF versions of the article.
References
Li, S. et al. Nat. Immunol. 15, 195–204 (2013).
Fourati, S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01329-5 (2022).
Sweeney, T. E., Wong, H. R. & Khatri, P. Sci. Transl. Med. 8, 346ra91 (2016).
Hagan, T. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01328-6 (2022).
Bradley, T. et al. Cell 175, 387–399.e17 (2018).
Thurmond, S., Wang, B., Song, J. & Hai, R. Viruses 10, 712 (2018).
Klein, S. L. & Flanagan, K. L. Nat. Rev. Immunol. 16, 626–638 (2016).
Rondy, M. et al. J. Infect. 75, 381–394 (2017).
Klein, S. L., Jedlicka, A. & Pekosz, A. Lancet Infect. Dis. 10, 338–349 (2010).
Atyeo, C. G. et al. Nat. Commun. 13, 3571 (2022).
Arunachalam, P. S. et al. Nature 596, 410–416 (2021).
Wang, W. et al. J. Biol. Rhythms 37, 124–129 (2022).
Acknowledgements
I.P.-P. and A.J.M. are funded by US National Institutes of Health/National Institute of Allergy and Infectious Diseases UM1 AI 00645 and the Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
A.J.M. is a consultant to and SAB member of Osivax and of Oxford Vacmedix.
Rights and permissions
About this article
Cite this article
Pedroza-Pacheco, I., McMichael, A.J. Immune signature atlas of vaccines: learning from the good responders. Nat Immunol 23, 1654–1656 (2022). https://doi.org/10.1038/s41590-022-01361-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-022-01361-5
