Mechanisms that explain the hygiene hypothesis for allergy and asthma are unclear. A mouse model that cohouses ‘dirty’ pet-store mice with clean laboratory mice might help to understand this immunology.
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Umetsu, D.T. Understanding microorganisms in the prevention of allergy. Nat Immunol 23, 1657–1658 (2022). https://doi.org/10.1038/s41590-022-01356-2