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Notch gives early T cell progenitors time to grow up

A stage-specific enhancer augments Notch1 signaling from the early thymic progenitor (ETP) through double-negative thymocyte stages. Enhanced Notch1 activity is required for T cell lineage differentiation at the later end of this developmental interval, but Notch1 also suppresses precocious T lineage commitment in ETPs and promotes their expansion as multi-lineage progenitors.

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Fig. 1: Notch1 signaling supported by a double-negative specific enhancer controls intrathymic T cell differentiation.

References

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This is a summary of: Georgopoulos, K. et al. A double-negative thymocyte specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection. Nat. Immunol. https://doi.org/10.1038/s41590-022-01322-y (2021).

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Notch gives early T cell progenitors time to grow up. Nat Immunol 23, 1523–1524 (2022). https://doi.org/10.1038/s41590-022-01323-x

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  • DOI: https://doi.org/10.1038/s41590-022-01323-x

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