Intestinal group 3 innate lymphoid (ILC3) cells exhibit increased mobility in response to flagellin-mediated inflammation. This ‘patrolling’ behavior promotes IL-22 diffusion and prevents intestinal epithelial cell death. Enhanced ILC3 dynamics rely on environmental cues and suggest a prominent ILC3 tissue adaptation that reinforces intestinal barrier integrity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Caruso, R., Lo, B. C. & Núñez, G. Host–microbiota interactions in inflammatory bowel disease. Nat. Rev. Immunol. 20, 411–426 (2020). This review summarizes the complex interactions between intestinal microorganisms and the intestinal barrier.
Serafini, N., Vosshenrich, C. A. J. & Di Santo, J. P. Transcriptional regulation of innate lymphoid cell fate. Nat. Rev. Immunol. 15, 415–428 (2015). This review summarizes the heterogeneity of innate lymphoid cells and their development.
Klose, C. S. N. & Artis, D. Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity. Cell Res. 30, 475–491 (2020). This review summarizes the emerging roles of innate lymphoid cells in tissue homeostasis and inflammation.
Serafini, N. et al. Trained ILC3 responses promote intestinal defense. Science 375, 859–863 (2022). This article describes the role of ILC3 cells after pathogen rechallenge and the existence of memory ILC3 cells.
Satoh-Takayama, N. et al. The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells. Immunity 41, 776–788 (2014). This article describes the importance of the topography of intestinal ILC3 cells for mucosal defense.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Jarade, A. et al. Inflammation triggers ILC3 patrolling of the intestinal barrier. Nat. Immunol. https://doi.org/10.1038/s41590-022-01284-1 (2022).
Rights and permissions
About this article
Cite this article
Patrolling ILC3 cells monitor intestinal tissue in response to inflammation. Nat Immunol 23, 1305–1306 (2022). https://doi.org/10.1038/s41590-022-01299-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-022-01299-8