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Patrolling ILC3 cells monitor intestinal tissue in response to inflammation

Intestinal group 3 innate lymphoid (ILC3) cells exhibit increased mobility in response to flagellin-mediated inflammation. This ‘patrolling’ behavior promotes IL-22 diffusion and prevents intestinal epithelial cell death. Enhanced ILC3 dynamics rely on environmental cues and suggest a prominent ILC3 tissue adaptation that reinforces intestinal barrier integrity.

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Fig. 1: ILC3 cells patrol intestinal villi.


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This is a summary of: Jarade, A. et al. Inflammation triggers ILC3 patrolling of the intestinal barrier. Nat. Immunol. (2022).

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Patrolling ILC3 cells monitor intestinal tissue in response to inflammation. Nat Immunol 23, 1305–1306 (2022).

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