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ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination

A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.

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Fig. 1: Kinetic proofreading for ligand discrimination by the TCR requires full activation of ZAP70.


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Correspondence to Mahima Swamy.

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Swamy, M. ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination. Nat Immunol 23, 1293–1294 (2022).

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