A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.
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Swamy, M. ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination. Nat Immunol 23, 1293–1294 (2022). https://doi.org/10.1038/s41590-022-01297-w
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DOI: https://doi.org/10.1038/s41590-022-01297-w