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STROMAL IMMUNOLOGY

A common activator of tissue-remodeling fibroblasts across tissues

Nature Immunology volume 23, pages 1295–1296 (2022)Cite this article

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ETS1 regulates tissue-remodeling properties of specific fibroblast subtypes in the synovium, gut and cancer and thus emerges as a novel cross-tissue therapeutic target for modulation of pathogenic fibroblast activation.

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Fig. 1: A possible dichotomy between ETS1 and PU.1 fibroblasts.

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Authors and Affiliations

  1. Center of Experimental Rheumatology, Department of Rheumatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland

    Caroline Ospelt

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  1. Caroline Ospelt
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Correspondence to Caroline Ospelt.

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The author declares no competing interests.

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Ospelt, C. A common activator of tissue-remodeling fibroblasts across tissues. Nat Immunol 23, 1295–1296 (2022). https://doi.org/10.1038/s41590-022-01294-z

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