Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNOTHERAPY

The systemic effect of type 1 interferon responsiveness on tumor immunotherapy

Nature Immunology volume 23, pages 1141–1143 (2022)Cite this article

Subjects

Immune checkpoint blocking therapies do not always work and come with some risks, but identifying non-responders and patients at risk of adverse events is becoming easier and more accurate.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Workflow for defining the outcome of PD-1 blockade therapy on T cell responsiveness to type I IFNs.

References

  1. Quesada, J. R. et al. N. Engl. J. Med. 310, 15–18 (1984).

    Article  CAS  Google Scholar 

  2. Zitvogel, L. et al. Nat. Rev. Immunol. 15, 405–414 (2015).

    Article  CAS  Google Scholar 

  3. Boukhaled, G. M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01262-7 (2022).

    Article  PubMed  Google Scholar 

  4. Zhang, T. et al. MedComm 2, 618–653 (2021).

    Article  CAS  Google Scholar 

  5. Boukhaled, G. M., Harding, S. & Brooks, D. G. Annu. Rev. Pathol. 16, 167–198 (2021).

    Article  CAS  Google Scholar 

  6. Benci, J. L. et al. Cell 167, 1540–1554.e12 (2016).

    Article  CAS  Google Scholar 

  7. Liu, J. et al. Nat. Can. 2, 457–473 (2021).

    Article  CAS  Google Scholar 

  8. Bai, X. et al. Clin. Cancer Res. 27, 5993–6000 (2021).

    Article  CAS  Google Scholar 

  9. Nishino, M. et al. Nat. Rev. Clin. Oncol. 14, 655–668 (2017).

    Article  CAS  Google Scholar 

  10. Litchfield, K. et al. Cell 184, 596–614.e14 (2021).

    Article  CAS  Google Scholar 

  11. Zhang, J. et al. Trends Immunol. 55, 738–748 (2022).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Shicheng Su & Erwei Song

  2. Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

    Shicheng Su & Erwei Song

Authors
  1. Shicheng Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Erwei Song
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Erwei Song.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Su, S., Song, E. The systemic effect of type 1 interferon responsiveness on tumor immunotherapy. Nat Immunol 23, 1141–1143 (2022). https://doi.org/10.1038/s41590-022-01275-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-022-01275-2

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer