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Deciphering immunoregulatory vulnerabilities in human cancers

Regulatory T cells that express high levels of IL-1R and ICOS display transcriptional features of antigen specificity, are highly suppressive and distinguish tumors from non-malignant inflamed tissues

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Fig. 1: A translational pipeline for the identification of immunoregulatory targets in tumor samples and matched non-malignant inflamed tissues.


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Correspondence to Alvaro Lladser or Sergio A. Quezada.

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Gálvez-Cancino, F., Lladser, A. & Quezada, S.A. Deciphering immunoregulatory vulnerabilities in human cancers. Nat Immunol 23, 995–996 (2022).

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