Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

INFLAMMATION

Gasdermin D pores for IL-33 release

In airway epithelial cells, exposure to allergen proteases induces the stress granules-mediated transfer of IL-33 from the nucleus to the cytoplasm and extracellular release through gasdermin D pores containing a newly described active fragment.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Fig. 1: Dual functions of gasdermin D (GSDMD) in mediating extracellular release of IL-1 family molecules.

References

  1. Cayrol, C. et al. Immunol. Rev. 281, 154–168 (2018).

    Article  CAS  Google Scholar 

  2. Moffatt, M. F. et al. N. Engl. J. Med. 363, 1211–1221 (2010).

    Article  CAS  Google Scholar 

  3. Chen, W. et al. Nat. Immunol. https://doi.org/10.1038/s41590-022-01255-6 (2022).

  4. Hammad, H. et al. Immunity 43, 29–40 (2015).

    Article  CAS  Google Scholar 

  5. Bessa, J. et al. J. Autoimmun. 55, 33–41 (2014).

    Article  CAS  Google Scholar 

  6. Martin, N. T. et al. Nat. Immunol. 17, 122–131 (2016).

    Article  CAS  Google Scholar 

  7. Kouzaki, H. et al. J. Immunol. 186, 4375–4387 (2011).

    Article  CAS  Google Scholar 

  8. Cayrol, C. et al. Nat. Immunol. 19, 375–385 (2018).

    Article  CAS  Google Scholar 

  9. Brusilovsky, M. et al. Nat. Immunol. 22, 1316–1326 (2021).

    Article  CAS  Google Scholar 

  10. Kesevardhara, S. et al. Annu. Rev. Immunol. 38, 567–595 (2020).

    Article  Google Scholar 

  11. Ding, J. et al. Nature 535, 111–116 (2016).

    Article  CAS  Google Scholar 

  12. Wang, J. et al. Int. J. Mol. Med. 49, 44 (2022).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hirohito Kita.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kita, H. Gasdermin D pores for IL-33 release. Nat Immunol 23, 989–991 (2022). https://doi.org/10.1038/s41590-022-01249-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-022-01249-4

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing