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Gasdermin D pores for IL-33 release

In airway epithelial cells, exposure to allergen proteases induces the stress granules-mediated transfer of IL-33 from the nucleus to the cytoplasm and extracellular release through gasdermin D pores containing a newly described active fragment.

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Fig. 1: Dual functions of gasdermin D (GSDMD) in mediating extracellular release of IL-1 family molecules.


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Correspondence to Hirohito Kita.

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Kita, H. Gasdermin D pores for IL-33 release. Nat Immunol 23, 989–991 (2022).

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