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TUMOR IMMUNOLOGY

Mapping the tumor-infiltrating immune cells during glioblastoma progression

Nature Immunology volume 23, pages 826–828 (2022)Cite this article

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The dynamic changes in immune cell infiltration that accompany glioblastoma (GBM) progression remain obscure. Single-cell RNA sequencing and flow cytometry are now used to deconstruct the tumor immune microenvironment of early- and late-stage GBMs.

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Fig. 1: Immune microenvironment at different stages of GBM and its modulation after the combination treatment with TMZ and radiotherapy.

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Acknowledgements

This work was supported by an American Cancer Society grant, Morgan Adams Brain Tumor Foundation grant and a V Foundation for Cancer Research to S.S.M. This work was also supported by a Cancer League of Colorado grant to S.L.C. and S.S.M.

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Authors and Affiliations

  1. Morgan Adams Brain Tumor Research Program, Department of Pediatrics, Division of Hematology/Oncology/Bone Marrow Transplant, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Senthilnath Lakshmanachetty & Siddhartha S. Mitra

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  1. Senthilnath Lakshmanachetty
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  2. Siddhartha S. Mitra
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Correspondence to Siddhartha S. Mitra.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Lakshmanachetty, S., Mitra, S.S. Mapping the tumor-infiltrating immune cells during glioblastoma progression. Nat Immunol 23, 826–828 (2022). https://doi.org/10.1038/s41590-022-01223-0

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