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Gene delivery of interleukin 2 treats neuro-inflammation in traumatic brain injury

Nature Immunology volume 23, pages 834–835 (2022)Cite this article

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Using a gene-delivery system, we show that ectopic expression of interleukin 2 (IL-2) within reactive astrocytes stimulates brain-specific expansion of resident regulatory T cells. Such gene delivery protects against neuroinflammation in several mouse models of disease and injury, with potential implications for patients with traumatic brain injuries.

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Fig. 1: Brain-delivered IL-2 protects against traumatic brain injury pathology.

References

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This is a summary of: Yshii, L. et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat. Immunol. https://doi.org/10.1038/s41590-022-01208-z (2022).

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Gene delivery of interleukin 2 treats neuro-inflammation in traumatic brain injury. Nat Immunol 23, 834–835 (2022). https://doi.org/10.1038/s41590-022-01209-y

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