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B cells regulate hematopoietic stem cells via cholinergic signaling

Nature Immunology volume 23, pages 476–478 (2022)Cite this article

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B-cell-derived acetylcholine initiates a circuit that prompts bone marrow stromal cells to secrete factors that restrain the blood-forming activity of hematopoietic stem cells in response to cardiovascular dysfunction.

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Fig. 1: B-cell-derived acetylcholine regulates hematopoiesis.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Sweta B. Patel & Eric M. Pietras

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  1. Sweta B. Patel
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  2. Eric M. Pietras
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Correspondence to Eric M. Pietras.

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The authors declare no competing interests.

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Patel, S.B., Pietras, E.M. B cells regulate hematopoietic stem cells via cholinergic signaling. Nat Immunol 23, 476–478 (2022). https://doi.org/10.1038/s41590-022-01172-8

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