A new genetic ‘recorder’ of long-term cell proliferation revealed substantial heterogeneity in the division history of central memory CD8+ T cells. Importantly, the extent of past proliferation was related to distinct transcriptional features and re-expansion potential, highlighting an unappreciated division of labor within the central memory T cell pool.
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References
Kretschmer, L. et al. Differential expansion of T central memory precursor and effector subsets is regulated by division speed. Nat. Commun. 11, 113 (2020). This paper shows that different phenotypic subsets present at the early phases of the T cell response adopt distinct replicative speeds.
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This is a summary of: Bresser, K. et al. Replicative history marks transcriptional and functional 10 disparity in the CD8+ T cell memory pool. Nat. Immunol. https://doi.org/10.1038/s41590-022-01171-9 (2022).
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Transcriptional state and function of CD8+ memory T cells is linked to past proliferation. Nat Immunol 23, 658–659 (2022). https://doi.org/10.1038/s41590-022-01169-3
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DOI: https://doi.org/10.1038/s41590-022-01169-3
