Cribriform plate-resident lymphatic endothelial cells respond to neuroinflammatory signals by inducing functional changes that enhance the capture and presentation of antigens from the cerebrospinal fluid and promote leukocyte interactions within the brain-draining lymphatics.
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References
Petrova, T. V. & Koh, G. Y. Biological functions of lymphatic vessels. Science 369, eaax4063 (2020). This Review summarizes the heterogeneity of adult lymphatic vessels exposed to different organ-specific microenvironments.
Aspelund, A. et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J. Exp. Med. 212, 991–999 (2015). This Article describes the complexity of the dural lympathic vasculature and shows that dural lymphatic vessels absorb CSF from the adjacent subarachnoid space and brain interstitial fluid via the glymphatic system.
Louveau, A. et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337–341 (2015). This article describes the molecular hallmarks of LECs, which carry both fluid and immune cells from the CSF and connect to the deep cervical lymph nodes.
Mezey, E. et al. An immunohistochemical study of lymphatic elements in the human brain. Proc. Natl Acad. Sci. USA 118, e2002574118 (2021). This Review summarizes the fine structure of lymphatic elements in the human brain based on imaging specific markers of the lymphatic endothelium.
Hsu, M. et al. Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells. Nat. Commun. 10, 1–14 (2019). This Article describes how lymphatic vessels near the cribriform plate undergo lymphangiogenesis in a VEGFC–VEGFR3-dependent manner during EAE, and drain both CSF and cells that were once in the CNS parenchyma.
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This is a summary of: Hsu, M. et al. Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate. Nat. Immunol. https://doi.org/10.1038/s41590-022-01158-6 (2022)
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Retention of immune cells in cribriform lymphatics is induced by neuroinflammation. Nat Immunol 23, 483–484 (2022). https://doi.org/10.1038/s41590-022-01162-w
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DOI: https://doi.org/10.1038/s41590-022-01162-w