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CANCER IMMUNOLOGY

Modulating the tumor-associated macrophage landscape

Nature Immunology volume 23, pages 481–482 (2022)Cite this article

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Targeting the post-translational modification enzyme QPCTL prevents the protection of CCL2 and CCL7 from N-terminal degradation, inactivates their chemotactic function and limits the recruitment of pro-tumoral macrophages.

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Fig. 1: QPCTL inhibition transforms the TAM landscape toward a less tumor-permissive profile.

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Authors and Affiliations

  1. Sorbonne Université, Inserm, CNRS, Centre d’Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France

    Alexandre Boissonnas & Christophe Combadière

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  1. Alexandre Boissonnas
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  2. Christophe Combadière
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Correspondence to Alexandre Boissonnas.

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Boissonnas, A., Combadière, C. Modulating the tumor-associated macrophage landscape. Nat Immunol 23, 481–482 (2022). https://doi.org/10.1038/s41590-022-01159-5

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