Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


γδ T cells monitor tissue health

Crosstalk between the dendritic epidermal γδ T cell (DETC) T cell receptor and Skint1 expressed by keratinocytes at steady state regulates epidermal barrier function and maintains DETC responsiveness.

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Epidermal Skint1–DETC interactions maintain immunosurveillance and barrier function.


  1. Nielsen, M. M., Witherden, D. A. & Havran, W. L. Nat. Rev. Immunol. 17, 733–745 (2017).

    CAS  Article  Google Scholar 

  2. Jandke, A. et al. Nat. Commun. 11, 3769 (2020).

    Article  Google Scholar 

  3. Boyden, L. M. et al. Nat. Genet. 40, 656–662 (2008).

    CAS  Article  Google Scholar 

  4. McKenzie, D. R. et al. Nat. Immunol. (2022).

    Article  PubMed  Google Scholar 

  5. Chodaczek, G., Papanna, V., Zal, M. A. & Zal, T. Nat. Immunol. 13, 272–282 (2012).

    CAS  Article  Google Scholar 

  6. Dalessandri, T., Crawford, G., Hayes, M., Castro Seoane, R. & Strid, J. Nat. Commun. 7, 12080 (2016).

    CAS  Article  Google Scholar 

  7. Matsue, H., Bergstresser, P. R. & Takashima, A. J. Immunol. 151, 6012–6019 (1993).

    CAS  PubMed  Google Scholar 

  8. MacLeod, A. S. et al. J. Immunol. 1950, 5695–5702 (2014).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Shruti Naik.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Subudhi, I., Naik, S. γδ T cells monitor tissue health. Nat Immunol 23, 348–349 (2022).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing