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T CELLS

An anion channel for cyclic dinucleotides in T cells

Nature Immunology volume 23, pages 157–158 (2022)Cite this article

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LRRC8C is an essential component of volume-regulated anion channel (VRAC) in T cells. By mediating the transport of cGAMP, LRRC8C inhibits T cell function by activating STING and the tumor suppressor p53.

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Fig. 1: LRRC8C-containing VRAC channel suppresses T cell function by mediating cGAMP transport and activating STING and p53.

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Authors and Affiliations

  1. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Jiachen Chu & Zhaozhu Qiu

  2. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Zhaozhu Qiu

Authors
  1. Jiachen Chu
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  2. Zhaozhu Qiu
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Correspondence to Zhaozhu Qiu.

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The authors declare no competing interests.

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Chu, J., Qiu, Z. An anion channel for cyclic dinucleotides in T cells. Nat Immunol 23, 157–158 (2022). https://doi.org/10.1038/s41590-021-01118-6

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