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CANCER IMMUNOLOGY

MHC-I presents: tumor surveillance in the epithelia by cell competition

When transformed cells emerge in an epithelium, their elevated class I MHC expression signals to normal neighboring epithelial cells, which respond by inducing their apical extrusion as a tumor-suppressive mechanism.

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Fig. 1: Transformed epithelial cells are eliminated by the surrounding healthy tissue.

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Correspondence to Ana Lima or Tristan A. Rodriguez.

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Lima, A., Rodriguez, T.A. MHC-I presents: tumor surveillance in the epithelia by cell competition. Nat Immunol 22, 1358–1360 (2021). https://doi.org/10.1038/s41590-021-01053-6

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