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Restoring control over autoimmunity by inducing Foxp3

Autoimmune inflammation and disease creates an environment that results in defective regulatory T (Treg) cell functions. New data show how induction of Foxp3 expression in these Treg cells during ongoing autoimmune inflammation can restore control over pathogenic T cell functions and resolve inflammation and pathology in mice.

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Fig. 1: The transgenic system for inducible Foxp3 expression in dysfunctional Treg cells.


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M.O. is supported by the MRC research grant MR/S000208/1.

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Correspondence to Masahiro Ono.

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Ono, M. Restoring control over autoimmunity by inducing Foxp3. Nat Immunol 22, 1080–1082 (2021).

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