Autoimmune inflammation and disease creates an environment that results in defective regulatory T (Treg) cell functions. New data show how induction of Foxp3 expression in these Treg cells during ongoing autoimmune inflammation can restore control over pathogenic T cell functions and resolve inflammation and pathology in mice.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ramsdell, F. & Ziegler, S. F. Nat. Rev. Immunol. 14, 343–349 (2014).
Gangaplara, A. et al. PLoS Pathog. 14, e1006985 (2018).
Laurence, A. et al. Immunity 26, 371–381 (2007).
Hu, W. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-01001-4 (2021).
Gavin, M. A. et al. Nature 445, 771–775 (2007).
Lin, W. et al. Nat. Immunol. 8, 359–368 (2007).
Bending, D. et al. EMBO J. https://doi.org/10.15252/embj.201899013 (2018).
Fontenot, J. D., Gavin, M. A. & Rudensky, A. Y. Nat. Immunol. 4, 330–336 (2003).
Levine, A. G., Arvey, A., Jin, W. & Rudensky, A. Y. Nat. Immunol. 15, 1070–1078 (2014).
Stadinski, B. D. et al. Nat. Immunol. 20, 1046–1058 (2019).
Acknowledgements
M.O. is supported by the MRC research grant MR/S000208/1.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Ono, M. Restoring control over autoimmunity by inducing Foxp3. Nat Immunol 22, 1080–1082 (2021). https://doi.org/10.1038/s41590-021-01008-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-021-01008-x
