Effective anticancer adoptive cellular therapy (ACT) requires sufficient infiltration of injected cytotoxic lymphocytes, but pathophysiology frustrates this. Regulator of G protein signaling 1 limits T cell trafficking to breast tumors and may be targeted to improve ACT.
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Fercoq, F., Carlin, L.M. “Mind the GAP”: RGS1 hinders antitumor lymphocytes. Nat Immunol 22, 802–804 (2021). https://doi.org/10.1038/s41590-021-00961-x
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DOI: https://doi.org/10.1038/s41590-021-00961-x
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