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Wnt–β-catenin as an epigenetic switcher in colonic Treg cells

Nature Immunology volume 22, pages 400–401 (2021)Cite this article

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In the colonic environment, sustained Wnt–β-catenin activation in regulatory T cells promotes epigenetic rewiring toward proinflammatory RORγt+ Treg cells, whose expansion parallels the disease progression from inflammatory bowel disease (IBD) to manifest colorectal cancer (CRC).

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Fig. 1: β-catenin-dependent epigenetic changes in the proinflammatory profile of Treg cells.

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Acknowledgements

This work was supported by grants from the Fondazione Cariverona, the Fondazione AIRC (23788), Cancer Research Institute (Clinic and Laboratory Integration Program, CLIP 2020), the European Research Commission (Euronanomed III, Joint Translational Call_2017, Project RESOLVE) and by the PRIN program of MIUR (CUP: B38D19000260006).

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  1. Department of Medicine, Section of Immunology, University of Verona, Verona, Italy

    Stefania Canè & Vincenzo Bronte

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  1. Stefania Canè
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  2. Vincenzo Bronte
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Correspondence to Stefania Canè or Vincenzo Bronte.

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Canè, S., Bronte, V. Wnt–β-catenin as an epigenetic switcher in colonic Treg cells. Nat Immunol 22, 400–401 (2021). https://doi.org/10.1038/s41590-021-00904-6

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