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IMMUNOMETABOLISM

Inflammation brakes mitochondrial metabolism in obesity

A vicious cycle, linking obesity with chronic inflammation, fuels the development and exacerbation of metabolic syndrome and other disorders. Modulation of mitochondrial energy metabolism via interleukin-1β signaling establishes a runaway positive-feedback loop that brings about and reinforces the sequelae of a high-fat diet.

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Fig. 1: Reprogramming of mitochondrial metabolism.

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Correspondence to Nektarios Tavernarakis.

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Tavernarakis, N. Inflammation brakes mitochondrial metabolism in obesity. Nat Immunol 21, 1143–1145 (2020). https://doi.org/10.1038/s41590-020-0780-8

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