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HUMORAL IMMUNITY

NR4As apply brakes on the B cell response

To trigger an adequate humoral immune response while ensuring self-tolerance, B cell activation is tightly controlled. A new study indicates that an NR4A-enforced built-in brake fine-tunes the early phase of transcriptional reprogramming induced by BCR stimulation.

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Fig. 1: Transient induction of NR4A proteins controls B cell response.

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Correspondence to Tanja A. Schwickert.

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Hill, L., Schwickert, T.A. NR4As apply brakes on the B cell response. Nat Immunol 21, 1137–1139 (2020). https://doi.org/10.1038/s41590-020-0775-5

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